Less frequently, the organism enters through a break in the skin by direct contact with tissue or body fluids of a plague–infected animal, for instance, in the process of skinning a rabbit or other animal. Dog-to-human transmission was reported in a 2014 outbreak in Colorado. Diagnosis of infection Plague is transmitted from animal to animal and from animal to human by the bites of infective fleas. Plague is infamous for killing millions of people in Europe during the Middle Ages. [] Survival of the bacillus in nature depends on flea-rodent interaction, and human infection does not contribute to the bacteria's persistence in nature. Plague or black death is an infection of rodents caused by Yersinia pestis and accidentially transmitted to humans by the bite of infected fleas. Plague is a disease caused by Yersinia pestis, a naturally-occurring bacterium found in many areas around the world, including the United States.There are several forms of plague, including pneumonic, bubonic, and septicemic plague. Spread of infection Incubation period. Domestic pets or rodents can carry the infected flea into the house. Pneumonic plague: human-to-human via air-borne droplets associated with coughing. NOTE: Unlike cats, dogs do not appear to develop pneumonic plague. Bubonic plague can advance and spread to the lungs, which is the more severe type of plague called pneumonic plague. Plague is a highly contagious, life-threatening infection now present in the US mainly in rural or semirural areas of the Southwest. Plague is most commonly transmitted from rodent to human by the bite of an infected flea, especially the oriental rat flea Xenopsylla cheopis. It was the disease behind the Black Death of the 14th century, … Strategy 1 Basic Information. It is caused by the bacterium, Yersinia pestis. The bubonic plague is the most common form of infection and targets the victim’s lymphatic system. Plague, infectious disease caused by Yersinia pestis, a bacterium transmitted from rodents to humans by the bite of infected fleas. Plague bacteria are killed within a few hours of exposure to sunlight, although they may persist for several weeks in water and on moist grains and pulses. Plague has caused some of the most-devastating epidemics in history. Plague is a zoonotic disease that primarily affects rodents; humans are incidental hosts. The disease follows urban and sylvatic cycles and is manifested in bubonic and pneumonic forms [note: bubo is derived from a Greek word for groin]. Plague may cause massive, often suppurative lymphadenopathy (buboes), severe pulmonary infection, and/or septicemia. I came up with a Cure Mode strategy which works for Bacteria on Mega Brutal.With some modifications, it seems to work on Viruses, Parasites, and a few other disease types but not quite as well since those are harder to defeat than Bacteria, and I have mostly just tested it on Bacteria. Primary plague pneumonia has a shorter incubation period of 1–4 days. Modes of Transmission. From 1–7 days; may be a few days longer in immunised people who develop illness. Plague Disease. Pneumonic plague occurs when Y. pestis infects the lungs, and is the most deadly form of the disease. The infection exists in three major plague forms: bubonic, septic, and pneumonic. Most often transmitted by the bite of infected rodent fleas. Humans usually get plague after being bitten by a rodent flea that is carrying the plague bacterium or by handling an animal infected with plague. NOTE: Cats also can develop pneumonic plague, and cat to human transmission has been reported. 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