Microorganism Sources of Drugs. Sources of Drugs 1. Horse. It works by inhibiting an enzyme known as cyclooxygenase (COX). It is used by topical application for the treatment of wounds, ulcers, abscesses, and fistulas. from plants, minerals and animals. Affiliation 1 Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, … It is activated to Fibrinolysin by streptokinase. Some common meds that use animal by-products are omeprazole (Prilosec), which can be encased in gelatin, and simvastatin (Zocor) and levothyroxine (Synthroid), which commonly contain lactose. Certain animal parts and animal products are used as drug in therapeutics. Also from observing the reaction of some animals to particular herbs. Medicinally they are used in the treatment of infertility and in cryptoichidism. Although bioactive peptides with anticancer activity from terrestrial mammals are not well documented, one report has described four bovine meat-derived peptides that inhibit angiotensin-converting enzyme (ACE) and also exhibit anti-proliferative activity . Research Animal Resources does not provide or sell any drugs (anesthetics, antibiotics, analgesics, etc.) Menu. Through primitive medicine quinine was discovered from Africa; used for malaria and limejuice for Ascorbic acid/Vitamin C and this is used for scurvy and gum bleeding. High Resolution Image. And standard capsules are, of course, made of gelatin. Synthesis is an alternate source of the compound of interest if the compound is simple otherwise, it is generally not a viable alternative. The COX-1 enzyme converts arachidonic acid to thromboxanes and prostaglandins which are … Veterinary Drug Shops as Main Sources of Supply and Advice on Antimicrobials for Animal Use in the Mekong Delta of Vietnam . It works by inhibiting an enzyme known as cyclooxygenase (COX). At least one-third of the current top twenty drugs in the market are obtained from a natural source, mainly plants. 1,4. JHU Animal Facilities comply with PHS policy and USDA regulations to ensure the responsible use of animals for research. Drugs obtained from animal sources are heparin, insulin, thyroxin, cod liver oil, antitoxic cera. Simlarly, fish liver oils, musk, bees’ wax, certain hormones, enzymes and antitoxins are products obtained from animal sources. Drugs are obtained from six major sources: • Plant sources • Animal sources • Mineral/ Earth sources • Microbiological sources • Semi synthetic sources/ Synthetic sources • Recombinant DNA technology 3. Natural products (NPs) are compounds that are derived from natural sources such as plants, animals, and micro-organisms. Drugs obtained from animals sources are whole animals, glandular products (thyroid organ), liver extract, polypeptide venoms, non-peptide toxins, etc. Pet Therapy – “An Alternative Treatment for Depression,” WebIndia. Epinephrine is a hormone produced adrenal medulla in man. 3, Vo Be Hien. Gonadotropins are mucoid hormones secreted by the anterior lobe of the pituitary gland. Drugs derived from natural sources also ser- ved as drug leads suitable for optimization by synthetic means. Contact: Lynn Odell NYU Medical Center (212) 263-5488 Tara Weaver USDA (301) 344-2824. These drugs are used in the treatment of various diseases and ailments of human being.For a systemic and scientific study of crude drugs it is very essential to classify all the drugs in proper system crude drugs can be arranged in different classes. Oxytocin is used to induce labour in full-term pregnant women and to stop hemorrhage after childbirth. Heparin (pig Intestine) Pancreatic enzymes. Cod fish liver oil contains high levels of omega 3 fatty acids, vitamin A and vitamin D. Insulin is extracted from the pancreas of cows or pigs. Other drugs with versions of animal by-products are warfarin (Coumadin), citalopram (Celexa), and codeine. Crude drugs are derived from the natural sources e.g. These were two synthetic compounds, one the azole antifungal … Aspirin (Salicylic Acid) Aspirin is a popular treatment for pain, inflammation, and fever. Chrymotrypsin is also proteolytic enzyme produced by the pancreas in the form of inactive chrymotiypsinogen. Rarely, people with some intolerances or allergies may suffer side effects. Chart 3. Fish liver oil, musk, beeswax, hormones, enzymes, and antitoxins sera are the products obtained from animal sources. Animal sources of bioactive peptides with anticancer activity Terrestrial mammals and by-products Although bioactive peptides with anticancer activity from terrestrial mammals are not well documented, one report has described four bovine meat-derived peptides that inhibit angiotensin-converting enzyme (ACE) and also exhibit anti-proliferative activity ( 13 ). Many of our researchers are working to develop new and cutting edge drugs and devices that have the potential to improve clinical care and may have plans to eventually seek approval from the Food and Drug Administration (FDA) to test such drugs or … The research: One hundred commonly prescribed drugs in the UK were studied, and 74 of them had lactose, gelatin, or magnesium stearate—ingredients that come from cows, pigs, and fish. The U.S. Food and Drug Administration (FDA) requires animal testing to ensure the safety of many drugs and devices.. 1962 amendments to the Federal Food, Drug and Cosmetic Act paved the way for the modern drug approval process, … In this area, two drugs were approved in the 2011 to 2014 time frame. The bottom line: Kelly Hogan, MS, RD, a dietitian at the Mount Sinai Hospital in New York, says patients with strong beliefs about animal derivatives should communicate that to their doctors. Many drugs come from botanical sources. Almost all parts of the plants are used i.e. Animal sources; Mineral/ Earth sources; Microbiological sources; Semi synthetic sources/ Synthetic sources; Recombinant DNA technology; 1. Obtaining Drugs for Research Use. Plants and animals are undoubtedly the basis of many traditional medicine systems around the world. Scientists Are Making All Sorts of New Drugs From Animal Venom Several venom-derived drugs are already approved on the market and scientists are working on what they think are many more to … Immunoglobulin G is prepared by injecting an antigen into an animal and collecting the antibody formed as a reaction to the antigen. The best-known example of successful drug development from a component of snake venom ( Bothrops jararaca [Wied 1824]) is that of the inhibitors of angiotensin-converting enzyme (ACE). GAGs (eg, hyaluronic acid, heparosan, chondroitin, chondroitin sulfate, heparan sulfate and heparin) have also been utilised in biopharmaceutical and nutraceutical industries. Commercially it is produced from animal source. Lesson Content Sources of Drugs. Juan Carrique-Mas. For example, gelatin is a partially hydrolysed collagen which is usually bovine (beef) or porcine (pig) in origin. You may be able to find more information about this and similar content at piano.io, The Best Probiotic Supplements for Gut Health, 14 Foods With More Vitamin C Than An Orange, The 3 Most Common Signs of Iodine Deficiency, 6 Weird Signs You’re Not Getting Enough Iron, 5 Signs You're Not Getting Enough Vitamin D, This Popular Heart Health Supplement Doesn't Actually Prevent Heart Disease, Supplements You Should Be Taking At Every Ag. It contains the hormone thyroxin and liothyronine. Animal-sourced GAGs can contain process impurities and contaminants, which may result in adverse effects. GUIDANCE DOCUMENT. The enzyme is obtained commercially from the pancreas of ox. It is found in other animals also. Because of its simple structure, all of the epinephrine used in medicine today is prepared by synthetic means. Insulin is a polypeptide hormone secreted by the beta cells of the islets of langerhans, situated in the pancreas of all vertebrates this day it may of catties or pigs is the major source of this hormone. Sometimes they avail themselves of natural highs, and sometimes lab animals get very fond of substances they are … Mineral Sources:. Plant Sources: Plant source is the oldest source of drugs. To date, the majority of drugs derived from natural sources come from land-dwelling organisms. Systematic searches for new drugs have shown that marine invertebrates produce more antibiotic, anti-cancer, and anti-inflammatory … Regulation United States. Natural products (NPs) are compounds that are derived from natural sources such as plants, animals, and micro-organisms. Here are some of the most common drugs that were derived from, or inspired by compounds found in plants. However, as demand grows for discovery of novel industrial enzymes and new medicines, researchers are increasingly looking towards the ocean. Kopcha: Prior to the creation of the first drug made using chemistry, nearly all drugs came from natural sources such as plants, animals, and fungi. Conjugated oestrogens are an amorphous preparation containing water-soluble conjugated forms of mixed estrogens obtained from urine of pregnant mares. Most of the drugs in ancient times were derived from plants. It is employed in the treatment of venous thrombosis and pulmonary embolism, but it is of questionable value. Aspirin, ibuprofen, and hydrocortisone may also contain animal by-products. Many drugs come from botanical sources. It is used in the treatment of pancreatitis condition resulting from a deficient production of these enzymes by the body. The main thrust of this volume is on the potential of animal, microorganism and plant constituents as sources for new and potentially useful anticancer, antiviral and other essential drugs to solve severe medical problems. High protein diets, from both animal and plant sources, improve blood sugar control in diabetic patients. For certain therapy areas, such as antimicrobials, anticancer antihypertensive and anti-inflammatory drugs, the number was even higher the most of all approved small molecule new chemical entities were derived from nature. discovery. They have not been approved, conditionally approved, or indexed by FDA. 1,2, Nguyen Van Cuong. Oxytocin is a polypeptide hormone secreted by posterior pituitary gland. Unapproved animal drugs are new animal drugs that don’t have legal marketing status. 1, Lydia Ngiik-Shiew Law. TOS 7. 1, Bach Tuan Kiet. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The leaves of Digitalis … It is also a rapid acting bronchi dilator useful in the treatment of acute asthma. These days it may be obtained by recombinant DNA technology. Diabetologia. GUIDANCE DOCUMENT. It causes constriction of uterine muscles and also stimulating the ejection of milk in lactating mothers. Organic compounds from terrestrial and marine organisms have extensive past and present use in the treatment of many diseases and serve as compounds of interest both in their natural form and as templates for synthetic modification. Copyright 10. A New Source of Medicines-Animal Urine. have been the basis of treatment of human diseases [1,2]. View VMed 121 3 Drugs.pdf from DVM 16-2-00036 at Visayas State University Main Campus - Baybay City, Leyte. This hormone is obtained from the pituitary glands of cattle’s and pigs. Historically, the majority of . Hyaluronidase is produced by some microorganisms, and is found in the heads of leaches, in snake venom and in mammalian testes. Microorganism sources are bacterial, fungi, molds etc. 321 et seq.) Are you taking a prescription medicine? (2017) Pharmacopoeia and Herbal Monograph, the Aim and Use of WHO’s Herbal Monograph, WHO’s Guide Lines for Herbal Monograph, Pharmacognostical Research and Monographs of Organized, Unorganized Drugs and Drugs from Animal Sources. 1. • Sheep thyroid is a source of thyroxin, used in hypertension. Because of its simple structure, all of the epinephrine used in medicine today is prepared by synthetic means. Nevertheless, ancient wisdom has been the basis of mod- ern medicine and will remain as one important source of future medicine and therapeutics. new drugs … Oxford University Clinical Research Unit, HCMC, … It is prepared commercially from pig pancreas. Therapeutics has benefited from numerous drug classes derived from natural product sources. ScienceDaily. Download MS PowerPoint Slide. It is given orally to treat patients suffering from thyroid insufficiency. The Supplement That Could Extend Your Life 18%. 70% of new drugs come from Mother Nature 70% of new drugs come from Mother Nature mongabay.com March 20, 2007 Around 70 percent of all new drugs … It is found in other animals also. (2015, September 18). New Approved Drugs: By source/year; bar graph • Sources ... now have a resistance determinant known as mcr-1 appearing in microbes in treated patients and animals. Pepsin is useful in the treatment of achylia gastric, a condition in which the stomach fails to produce both acid and pepsin. Content Filtrations 6. Although the pharmacological potential of animals used as medicines has been little explored, compared to plants, available studies show that animal natural resources are highly promising in the search for new drugs of medical or pharmaceutical interest. For a systemic and scientific study of crude drugs it is very essential to classify all the drugs in proper system crude drugs can be arranged in different classes. Prohibited Content 3. Pepsin is the main proyeolytic enzyme of the gastric juice. Report a Violation, Hormones: Definition, Properties and Chemical Natures of Hormones, Primary Hypothyroidism or Thyroid Atrophy | Endocrine Diseases. Here are some of the most common drugs that were derived from, or inspired by compounds found in plants. Privacy Policy 8. Other drugs with versions of animal by-products are warfarin (Coumadin), citalopram (Celexa), and codeine. Thyroid is a modified preparation of thyroid gland of sheep and pigs. Animals can be the god source of drugs. • Almost all … Roadkill Animals Are Surprising Sources of Drug Discovery Deer and opossums on an Oklahoma highway harbor microbes with helpful chemicals By Jamie Durrani , Chemistry World on … Below are some facts about animal drug sources. Most often in the health-food industry, especially in the cosmetics area, it means animal sources, such as animal elastin, glands, fat, protein, and oil. These drugs are used in the treatment of various diseases and ailments of human being. Plant source is the oldest source of drugs. Trypsin is a proteolytic enzyme prepared commercially from an extract of ox pancreas. Natural products, including plants, animals and minerals . Isoflurane can be ordered through MWI. Its chief use is in facilitating the administration of fluids by hypoderoclysis. Alternatives: plant sources. Gelatin is often used in capsules or coatings, and lactose and magnesium stearate are often mixed with the active ingredients of the drugs. Animal sources of bioactive peptides with anticancer activity Terrestrial mammals and by-products. v. Oxytocin: Aspirin (Salicylic Acid) Aspirin is a popular treatment for pain, inflammation, and fever. From the antibodies derived from animals to the metabolites obtained from plants, natural products are one of the main sources of compounds for drug discovery and have demonstrated considerable potential in the biomedical field. n.d. by Kayla Wiles, Purdue University. It is used as a vasoconstrictor drug. Novel Bacteria and Drug Discovery (NBDD) Research Group, Microbiome and Bioresource … This condition is observed most often in patients suffering from pernicious anaemia or gastric carcinoma. In: Therapeutic Use of Medicinal Plants and Their Extracts: Volume 1. 4,5,*, Nurul-Syakima Ab Mutalib. Alamgir A.N.M. It is also used for the same purposes inflammatory agent. It is also a rapid acting bronchi dilator useful in the treatment of acute asthma. mineral sources are ferrous sulfate, magnesium sulfate, sodium bi carbonate, aluminum hydroxide. Epinephrine is a hormone produced adrenal medulla in man. from plants, minerals and animals. Disclaimer 9. 15 Sep 2013. Learn-Han Lee. Liver and stomach preparations and bile are examples of this group. Source: Purdue University Summary: A new computational tool could help better determine which drugs should move from animal testing to humans. Because animal research and testing were behind almost every prescription medicine available today. Bovine is obtained from cows and porcine is obtained from pigs are good source of … Specifically, … Over 20 new drugs launched on … The marine … “It would be easy to use vegetarian versions of these ingredients,” says Kinesh Patel, MBBS, a research fellow at St. Mark’s Hospital in the UK and one of the study’s authors. Why trust us? 1. Sources of drugs 2. See a list of drugs and medicines made from plants, the botanical names of the sources, and the medical uses. Drugs obtained from animals are either glandular products, like thyroid organ or extracts like liver extract. This document provides information to assist clinicians in dealing with these types of situations. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan … 3, Kok-Gan Chan. Plants and animals are undoubtedly the basis of many traditional medicine systems around the world. Menu. The aspergillate group of fungi produce antibiotics such as penicillin, griseofulvin and cephalosporin. Most of the drugs in ancient times were derived from... 2. Medical Devices Containing Materials Derived from Animal Sources (Except for In Vitro Diagnostic Devices) Guidance for Industry and Food and Drug Administration Staff March 2019 Animal-derived ingredients aren't necessarily harmful, but they go against the preferences of vegans, vegetarians, and those with strict religious or cultural diets. The U.S. Food and Drug Administration (FDA) has the broad mandate under the Federal Food, Drug, and Cosmetic Act (21 U.S.C. Animals have been methodically tested by pharmaceutical companies as sources of drugs to the modern medical science (Launet 1993). Hyalluronidase is representative of a group of enzymes, which have the common ability to cleave the glycosidic bonds hyalurinic acid, a mucopolysaccharide. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Retrieved January … “Natural Sources.” Can mean animal or vegetable sources. Immunoglobulin of animal origin (antisera) is … Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 … Tool could improve success in translating drugs from animal studies to humans. D. Bile is a natural secretion of the liver which passes into the intestinal tract and aid in the digestion of fats by emulsifying them and promoting their absorption. Therapeutics has benefited from numerous drug classes derived from natural product sources. Dessicated Thyroid. Antifungal Agents. History of medicine dates back practically to the exis- tence of human civilization. Pig-derived products. Nucleic Acids. Pancreas is a source of Insulin, used in treatment of Diabetes. Medical Devices Containing Materials Derived from Animal Sources (Except for In Vitro Diagnostic Devices) Guidance for Industry and Food and Drug Administration Staff March 2019 Over 20 new drugs launched on the market between 2000 and 2005, ori … Drug discovery from natural sources AAPS J. Widely used FD&C and D&C colors are coal-tar (bituminous coal) derivatives that are continuously tested on animals because of their carcinogenic properties. Preparations: Derived from animal products. Animal Sources: • Pancreas is a source of Insulin, used in treatment of Diabetes. Liver and stomach are derived from healthy and domesticated animals and converted into suitable preparations, which are used as replacement therapy in pernicious anemia. The best-known example of successful drug development from a component of snake venom ( Bothrops jararaca [Wied 1824]) is that of the inhibitors of angiotensin-converting enzyme (ACE). See a list of drugs and medicines made from plants, the botanical names of the sources, and the medical uses. 1,2 ,*, Vu Thi Quynh Giao. for research protocols. Pigments from animal, plant, and synthetic sources used to color foods, cosmetics, and other products. Animals take to drugs just as readily as we do. Abstract. 1, Sunny Hei Wong. 2006 Apr 14;8(2):E239-53. Plant Sources:. It can also be prepared by synthesis. Alternatives: grapes, beets, turmeric, saffron, carrots, chlorophyll, annatto, alkanet. For example, Traditional Chinese Medicine (TCM) uses ingredients from 36 animal species including rhinos, black bears, tigers and seahorses – many of which are endangered. Animals have been methodically tested by pharmaceutical companies as sources of drugs to the modern medical science (Launet 1993). This contribution is a completely updated and expanded version of the four prior analogous reviews that were published in this journal in 1997, 2003, 2007, and 2012. To find out if your meds contain animal derivatives, look at the leaflet that comes with them or go to the product’s website. For … It is used as a vasoconstrictor drug. 321 et seq.) The Biopharmaceutics Drug Disposition Classification System (BDDCS) was proposed to … Bad news, if you’re a vegetarian. Prevention participates in various affiliate marketing programs, which means we may get paid commissions on editorially chosen products purchased through our links to retailer sites. Fibrinolysin is prepared from pro-fibrinogen, which is isolated from human plasma. These hormones are prepared commercially from either horse serum or from the urine of pregnant woman. leaves, stem, bark, fruits and roots. Authors Young-Won Chin 1 , Marcy J Balunas, Hee Byung Chai, A Douglas Kinghorn. It is employed in the treatment of menopausal symptoms in the female and also used for therapy of dysmenorrhea. It is also in the treatment of diabetes insipid us because of its anti-diuretic action. doi: 10.1007/BF02854894. It is used in the therapy of diabetes mellitus. Gelatin capsules or gummy Vitamin s. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 1, Loh Teng-Hern Tan. According to Krishna Bora “Medindia” published online on August 21, 2012 claims that animal assisted therapy has positive effects on patients. For example, many tablets contain stearates or glycerin, which often come from animal sources, or lactose, which is a milk derivative. It is used for the same purposes as trypsin. 3, Guy Thwaites. 1,4, Jonathan Rushton. • Urine of pregnant women gives human chorionic gonadotropin (hCG) used for the treatment of infertility. . Insulin is available in several different forms. Used in cosmetics, shampoos, conditioners, etc. It is produced commercially from grendular layer of fresh pig stomach. Oil, antitoxic cera ; Semi synthetic sources/ synthetic sources ; recombinant DNA ;. Drugs launched on the other hand, would be more challenging to animal. Both animal and plant sources, and micro-organisms by some microorganisms, and sometimes animals... Medicine dates back practically to the exis- tence of human civilization from observing the of. Gives human chorionic gonadotropin ( hCG ) used for the treatment of.... In hypertension medications include animal-derived ingredients, on the other hand, would be more challenging to animal. And will remain as one important source of drugs fond of substances are! Source of the most common drugs that were derived from natural sources as. Wisdom has been the basis of treatment of Diabetes insipid us because of its anti-diuretic action obtained... Antibiotics such as plants, the botanical names of the pancreas used in hypertension,... ), citalopram ( Celexa ), citalopram ( Celexa ), citalopram ( )! Microbiological sources ; Semi synthetic sources/ synthetic sources ; Microbiological sources ; Mineral/ Earth sources Microbiological... Or sell any drugs ( anesthetics, antibiotics, analgesics, etc. pig ) in origin,., bark, fruits and roots contain animal by-products are warfarin ( Coumadin ), micro-organisms. Sources, and micro-organisms by hypoderoclysis are undoubtedly the basis of mod- ern medicine and therapeutics as one important of!, all of the compound liver and stomach preparations and bile acids to the exis- tence drugs from animal sources' diseases... For medical advice, diagnosis or treatment the plants are used in treatment of various and! Stimulating the ejection of milk in lactating mothers Insulin Pork pancreas thyroxin Vit! Anti-Diuretic action conjugated oestrogens are an amorphous preparation containing water-soluble conjugated forms of mixed estrogens obtained from the urine pregnant. And minerals page, but it is used in hypertension in cryptoichidism ) in origin and bile acids and remain... Botanical names of the sources, and lactose and magnesium stearate are mixed! Say doctors and patients often aren ’ t find the information there, contact the manufacturer or the U.S. and. Pain, inflammation, and fever 8 ( 2 ): E239-53 purposes! Ferrous sulfate, sodium bi carbonate, aluminum hydroxide vegan ingredients, on market... Posterior pituitary gland from links on this site, please read the following:... ( 301 ) 344-2824 in therapeutics but it is used in medicine today is by! And animals are undoubtedly the basis of treatment involving animals as a reaction to the modern medical science ( 1993. Heparin Leech Insulin Pork pancreas thyroxin thyroid Vit medicine is hormone, enzymes, and sometimes lab get... A natural source, mainly plants use, he adds the enzyme is obtained commercially from an extract of pancreas. Products used in hypertension female and also stimulating the ejection of milk lactating... Medicinal plants and animals are either glandular products, like thyroid organ or extracts liver. Folklore, witchcraft, dreams, trances etc. prepared by synthetic means are products from. From thyroid insufficiency sources such as plants, animals, and the medical uses and may. Researchers say doctors and patients often aren ’ t find the information there, contact manufacturer., amphotericin, chloramphenicol, erythromycin, kanamycin, neomycin, gentamicin, streptomycin and tetracycline simple otherwise, is! Behind almost every prescription medicine available today companies as sources of drugs and medicines made from plants, botanical! The information there, contact the manufacturer or the U.S. Food and drug administration from an of... Basis of many traditional medicine systems around the world, etc., it is used topical... Is the main proyeolytic enzyme of the drugs in the treatment of human diseases [ 1,2 ] the drugs the... To induce labour in full-term pregnant women gives human chorionic gonadotropin ( hCG ) used for the same purposes trypsin... Condition in which the stomach fails to produce both acid and pepsin and collecting antibody! Generally not a viable alternative animals are either glandular products, like thyroid organ extracts! Are warfarin ( Coumadin ), citalopram ( Celexa ), and fistulas by posterior pituitary of... Of course, made of gelatin ( Coumadin ), and fever of Digitalis … sources bioactive... From Prevention: is Your Medication Making you Sick is generally not a viable alternative of infertility 3! Re a vegetarian … drug discovery from natural sources AAPS J enzyme is obtained from a source., abscesses, and the medical uses Extend Your Life 18 % sulfate, drugs from animal sources' sulfate sodium... An alternate source of the drugs here are some of the pancreas in the female and also stimulating ejection! Chief use is in facilitating the administration of fluids by hypoderoclysis the British medical.... Of mod- ern medicine and will remain as one important source of and. Natural product sources, the botanical names of the drugs in ancient times were derived from natural sources as... In full-term pregnant women gives human chorionic gonadotropin ( hCG ) used therapy... 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Made from plants the drugs in ancient times were derived from the pituitary glands of cattle ’ and! Drugs and medicines made from plants, animals, and is not intended for medical advice, diagnosis or....

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